Dott. Loredana Bucciarelli

Sono un medico laureato in Italia e poi trasferito all'estero c/o la Columbia University di NYC per 6 anni dove svolgevo attività di ricerca.
Successivamente rientrata in Italia dove ho conseguito la specialità in Endocrinologia e Malattie del Ricambio ed il dottorato in Scienze dell'Invecchiamento c/o l'Università degli studi di Milano.
Attualmente ricopro il ruolo di Aiuto c/o H Multimedica IRCCS dove svolgo attività di ricerca clinica ed attività ambulatoriale (Diabetologia/Endocrinologia/Osteoporosi/Obesità/agobiopsie tiroidee ecoguidate)

• Endocrinologia
• Diabetologia

• Field of study: diabetes, cardiovascular disease, oxidative stress, endocrinology
• PhD Degree: 2006-Dec 2010 in “Aging Sciences” University “G. d’annunzio” of Chieti Graduation:70 magna cum laude /70
• Post-Doc Clinical Fellowship: 2001 - 2006 Columbia University New York NY
• Medical School: 1992-1998 Universita' Degli Studi "G. D'Annunzio" -Chieti, Italy 110 magna cum laude/110
• High School: ; 1986-1991 Liceo Scientifico "F. Masci" – Chieti, Italy
• Corso di formazione di ecografia tiroidea c/o Arcispedale S. Maria Nuova Reggio Emilia Direttore Prof. Valcavi
• Corso di diagnostica interventistica (FNAB) c/o Arcispedale S. Maria Nuova Reggio Emilia

• Italiano
• Inglese

• Columbia University NYC Grant for Post doctoral Research Fellow by Juvanile Diabetes Research Foundation

• Arterioscler Thromb Vasc Biol. 2001 Jun;21(6):905-10.
• Kislinger T1, Tanji N, Wendt T, Qu W, Lu Y, Ferran LJ Jr, Taguchi A, Olson K, Bucciarelli L, Goova M, Hofmann MA, Cataldegirmen G,D'Agati V, Pischetsrieder M, Stern DM, Schmidt AM
• Receptor for advanced glycation end products mediates inflammation and enhanced expression of tissue factor in vasculature of diabetic apolipoprotein E-null mice.
• Curr Atheroscler Rep. 2002 May;4(3):228-37
• Goova MT1, Li J, Kislinger T, Qu W, Lu Y, Bucciarelli LG, Nowygrod S, Wolf BM, Caliste X, Yan SF, Stern DM, Schmidt AM.
• Blockade of receptor for advanced glycation end-products restores effective wound healing in diabetic mice.
• Curr Atheroscler Rep. 2002 May;4(3):228-37.
• Wendt T1, Bucciarelli L, Qu W, Lu Y, Yan SF, Stern DM, Schmidt AM.
• Receptor for advanced glycation endproducts (RAGE) and vascular inflammation: insights into the pathogenesis of macrovascular complications in diabetes.
• Genes Immun. 2002 May;3(3):123-35.
• Hofmann MA1, Drury S, Hudson BI, Gleason MR, Qu W, Lu Y, Lalla E, Chitnis S, Monteiro J, Stickland MH, Bucciarelli LG, Moser B, Moxley G, Itescu S, Grant PJ, Gregersen PK, Stern DM, Schmidt AM.
• RAGE and arthritis: the G82S polymorphism amplifies the inflammatory response.
• Cell Mol Life Sci. 2002 Jul;59(7):1117-28.
• Bucciarelli LG1, Wendt T, Rong L, Lalla E, Hofmann MA, Goova MT, Taguchi A, Yan SF, Yan SD, Stern DM, Schmidt AM.
• RAGE is a multiligand receptor of the immunoglobulin superfamily: implications for homeostasis and chronic disease.
• Circulation. 2002 Nov 26;106(22):2827-35.
• Bucciarelli LG1, Wendt T, Qu W, Lu Y, Lalla E, Rong LL, Goova MT, Moser B, Kislinger T, Lee DC, Kashyap Y, Stern DM, Schmidt AM
• RAGE blockade stabilizes established atherosclerosis in diabetic apolipoprotein E-null mice.
• Am J Pathol. 2003 Apr;162(4):1123-37
• Wendt TM1, Tanji N, Guo J, Kislinger TR, Qu W, Lu Y, Bucciarelli LG, Rong LL, Moser B, Markowitz GS, Stein G, Bierhaus A, Liliensiek B,Arnold B, Nawroth PP, Stern DM, D'Agati VD, Schmidt AM.
• RAGE drives the development of glomerulosclerosis and implicates podocyte activation in the pathogenesis of diabetic nephropathy.
• Arterioscler Thromb Vasc Biol. 2003 Aug 1;23(8):1405-11. Epub 2003 Jun 19.
• Lalla E1, Lamster IB, Hofmann MA, Bucciarelli L, Jerud AP, Tucker S, Lu Y, Papapanou PN, Schmidt AM.
• Oral infection with a periodontal pathogen accelerates early atherosclerosis in apolipoprotein E-null mice.
• Arch Biochem Biophys. 2003 Nov 1;419(1):80-8
• Hudson BI1, Bucciarelli LG, Wendt T, Sakaguchi T, Lalla E, Qu W, Lu Y, Lee L, Stern DM, Naka Y, Ramasamy R, Yan SD, Yan SF, D'Agati V, Schmidt AM.
• Blockade of receptor for advanced glycation endproducts: a new target for therapeutic intervention in diabetic complications and inflammatory disorders.
• Circ Res. 2004 Feb 20;94(3):333-9. Epub 2003 Dec 11
• Harja E1, Bucciarelli LG, Lu Y, Stern DM, Zou YS, Schmidt AM, Yan SF.
• Early growth response-1 promotes atherogenesis: mice deficient in early growth response-1 and apolipoprotein E display decreased atherosclerosis and vascular inflammation.
• Naka Y1, Bucciarelli LG, Wendt T, Lee LK, Rong LL, Ramasamy R, Yan SF, Schmidt AM.
• RAGE axis: Animal models and novel insights into the vascular complications of diabetes.
• FASEB J. 2004 Dec;18(15):1818-25.
• Rong LL1, Yan SF, Wendt T, Hans D, Pachydaki S, Bucciarelli LG, Adebayo A, Qu W, Lu Y, Kostov K, Lalla E, Yan SD, Gooch C, Szabolcs M, Trojaborg W, Hays AP, Schmidt AM.
• RAGE modulates peripheral nerve regeneration via recruitment of both inflammatory and axonal outgrowth pathways.
• Ann N Y Acad Sci. 2005 Jun;1043:702-9
• Kaneko M1, Bucciarelli L, Hwang YC, Lee L, Yan SF, Schmidt AM, Ramasamy R
• Aldose reductase and AGE-RAGE pathways: key players in myocardial ischemic injury.
• Atherosclerosis. 2006 Mar;185(1):70-7. Epub 2005 Aug 1.
• Wendt T1, Harja E, Bucciarelli L, Qu W, Lu Y, Rong LL, Jenkins DG, Stein G, Schmidt AM, Yan SF
• RAGE modulates vascular inflammation and atherosclerosis in a murine model of type 2 diabetes
• Diab Vasc Dis Res. 2004 May;1(1):10-20
• Yan SF1, Ramasamy R, Bucciarelli LG, Wendt T, Lee LK, Hudson BI, Stern DM, Lalla E, DU Yan S, Rong LL, Naka Y, Schmidt AM.
• RAGE and its ligands: a lasting memory in diabetic complications?
• Antioxid Redox Signal. 2005 Nov-Dec;7(11-12):1588-600
• Hudson BI1, Wendt T, Bucciarelli LG, Rong LL, Naka Y, Yan SF, Schmidt AM.
• Diabetic vascular disease: it's all the RAGE.
• J Endocrinol Invest. 2005 Dec;28(11):1015-8
• Bucciarelli LG1, Pecori Giraldi F, Cavagnini F
• No mutations in TPIT, a corticotroph-specific gene, in human tumoral pituitary ACTH-secreting cells.
• Circulation. 2006 Mar 7;113(9):1226-34. Epub 2006 Feb 27
• Bucciarelli LG1, Kaneko M, Ananthakrishnan R, Harja E, Lee LK, Hwang YC, Lerner S, Bakr S, Li Q, Lu Y, Song F, Qu W, Gomez T, Zou YS, Yan SF, Schmidt AM, Ramasamy R
• Receptor for advanced-glycation end products: key modulator of myocardial ischemic injury
• J Endocrinol Invest. 2006 Dec;29(11):1021-2
• Lavezzi E, Fatti LM, Bucciarelli L, Bettinelli A, Scacchi M, Cavagnini F
• Monolateral visual loss due to sphenoid sinus mucocele: a rare complication of transsphenoidal surgery.
• J Neuroendocrinol. 2007 Mar;19(3):208-12.
• Pecori Giraldi F1, Bucciarelli LG, Saccani A, Scacchi M, Pesce S, Losa M, Cavagnini F
• Ghrelin stimulates adrenocorticotrophic hormone (ACTH) secretion by human ACTH-secreting pituitary adenomas in vitro.
• Free Radic Biol Med. 2007 Aug 15;43(4):511-8. Epub 2007 Mar 24
• Devangelio E1, Santilli F, Formoso G, Ferroni P, Bucciarelli L, Michetti N, Clissa C, Ciabattoni G, Consoli A, Davì G.
• Soluble RAGE in type 2 diabetes: association with oxidative stress
• Free Radic Biol Med. 2007 Nov 1;43(9):1255-62. Epub 2007 Jul 4
• Santilli F1, Bucciarelli L, Noto D, Cefalù AB, Davì V, Ferrante E, Pettinella C, Averna MR, Ciabattoni G, Davì G.
• Decreased plasma soluble RAGE in patients with hypercholesterolemia: effects of statins
• Diabetes. 2008 Jul;57(7):1941-51. doi: 10.2337/db07-0326. Epub 2008 Apr 16
• Bucciarelli LG1, Ananthakrishnan R, Hwang YC, Kaneko M, Song F, Sell DR, Strauch C, Monnier VM, Yan SF, Schmidt AM, Ramasamy R.
• RAGE and modulation of ischemic injury in the diabetic myocardium.
• Curr Med Chem. 2009;16(8):940-52
• Santilli F1, Vazzana N, Bucciarelli LG, Davì G
• Soluble forms of RAGE in human diseases: clinical and therapeutical implications.
• Diab Vasc Dis Res. 2009 Oct;6(4):249-61. doi: 10.1177
• Bucciarelli LG1, Pollreisz A, Kebschull M, Ganda A, Kalea AZ, Hudson BI, Zou YS, Lalla E, Ramasamy R, Colombo PC, Schmidt AM, Yan SF
• Inflammatory stress in primary venous and aortic endothelial cells of type 1 diabetic mice
• Cardiovasc Diabetol. 2013 Jun 27;12:97. doi: -12-97
• Ceriello A, Novials A, Ortega E, Canivell S, Pujadas G, La Sala L, Bucciarelli L, Rondinelli M, Genovese S.
• Vitamin C further improves the protective effect of GLP-1 on the ischemia-reperfusion-like effect induced by hyperglycemia post-hypoglycemia in type 1 diabetes.
• Diabetes Care. 2013 Dec;36(12):4104-8. doi: 10.2337/dc13-0750. Epub 2013 Oct 15
• Ceriello A1, Novials A, Ortega E, Canivell S, La Sala L, Pujadas G, Bucciarelli L, Rondinelli M, Genovese S.
• Vitamin C further improves the protective effect of glucagon-like peptide-1 on acute hypoglycemia-induced oxidative stress, inflammation, and endothelial dysfunction in type 1 diabetes.
• Eur Heart J. 2014 Feb;35(7):448-54. doi: 10.1093/eurheartj/eht456. Epub 2013 Nov 20.
• Colombo PC1, Onat D, Harxhi A, Demmer RT, Hayashi Y, Jelic S, LeJemtel TH, Bucciarelli L, Kebschull M, Papapanou P, Uriel N,Schmidt AM, Sabbah HN, Jorde UP.
• Peripheral venous congestion causes inflammation, neurohormonal, and endothelial cell activation.
• Diabetes Care. 2014 Jul;37(7):1938-43. doi: 10.2337/dc13-2618. Epub 2014 Mar 25.
• Ceriello A1, Novials A2, Canivell S2, La Sala L2, Pujadas G2, Esposito K3, Testa R4, Bucciarelli L5, Rondinelli M5, Genovese S5
• Simultaneous GLP-1 and insulin administration acutely enhances their vasodilatory, antiinflammatory, and antioxidant action in type 2 diabetes
• Cardiovasc Diabetol. 2014 Nov 19;13(1):140.
• Ceriello A, Esposito K, La Sala L, Pujadas G, De Nigris V, Testa R, Bucciarelli L, Rondinelli M, Genovese S.
• The protective effect of the Mediterranean diet on endothelial resistance to GLP-1 in type 2 diabetes: a preliminary report.

• Tiroidite di hashimoto
• Obesità
• Diabete mellito
• Osteoporosi
• Sindrome dell'ovaio policistico
• Tumore della tiroide
• Ipotiroidismo
• Ipercolesterolemia
• Ipertiroidismo
• Struma tiroideo
• Diabete mellito tipo 1 e nuove tecnologie
• Sindrome delle Ipoglicemie reattive
• Sindrome di Cushing e difetti dell'asse surrenali
• Malattia di Addison e difetti dell'asse surrenalico
• Adenomi ipofisari
• Iperprolattinemia (adenoma Ipofisario PRL secernente)
• Morbo di Graves-Basedow